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500 East Main Street, Branford, CT 06405 Professional Office / Medical Space in Branford, CT

$16.50 / SF 860 - 1,902 SF
500 East Main Street, Branford, CT: office space for lease, photo 1 of 15
500 East Main Street, Branford, CT: office space for lease, photo 2 of 15
500 East Main Street, Branford, CT: office space for lease, photo 3 of 15
500 East Main Street, Branford, CT: office space for lease, photo 4 of 15
500 East Main Street, Branford, CT: office space for lease, photo 5 of 15
500 East Main Street, Branford, CT: office space for lease, photo 6 of 15
500 East Main Street, Branford, CT: office space for lease, photo 7 of 15
500 East Main Street, Branford, CT: office space for lease, photo 8 of 15
500 East Main Street, Branford, CT: office space for lease, photo 9 of 15
500 East Main Street, Branford, CT: office space for lease, photo 10 of 15
500 East Main Street, Branford, CT: office space for lease, photo 11 of 15
500 East Main Street, Branford, CT: office space for lease, photo 12 of 15
500 East Main Street, Branford, CT: office space for lease, photo 13 of 15
500 East Main Street, Branford, CT: office space for lease, photo 14 of 15
500 East Main Street, Branford, CT: office space for lease, photo 15 of 15
500 East Main Street, Branford, CT 06405
500 East Main Street, Branford, CT 06405
500 East Main Street, Branford, CT 06405
500 East Main Street, Branford, CT 06405
500 East Main Street, Branford, CT 06405
500 East Main Street, Branford, CT 06405
500 East Main Street, Branford, CT 06405
500 East Main Street, Branford, CT 06405
500 East Main Street, Branford, CT 06405
500 East Main Street, Branford, CT 06405
500 East Main Street, Branford, CT 06405
500 East Main Street, Branford, CT 06405
500 East Main Street, Branford, CT 06405
500 East Main Street, Branford, CT 06405
500 East Main Street, Branford, CT 06405

For Lease Details

$16.50 / SF
860 - 1,902 SF
  • Property Type Office / Medical
  • Spaces 4
  • Total Space 5,964 SF
  • Status Active
  • Created 05/25/22
  • Updated 09/25/26

About 500 East Main Street, Branford, CT 06405

O,R&L Commercial is pleased to offer a 48,000 SF professional "Class A" Office / Medical building for Lease on East Main Street in the town of Branford, CT. Sound deadening insulation in interior walls creates a private, and quiet professional atmosphere. Two large elevators and ADA compliant bathrooms for accessibility. Large windows with lots of natural light potential. Availability includes: 860 SF, 1,765 SF, 1,902 SF, (3,667 SF contiguous) on the 3rd floor and 1,437 SF available on the 2nd floor with elevator access. The property offers ample on-site parking for patrons and exclusive tenant parking. Route 1 location with many area amenities nearby and convenient access to I-95 Exits 55 and 56. All existing tenants are professional / medical uses. Lease Rate: $16.50/SF NNN

4 Spaces available

Rent / SF: $16.50 Monthly Rent: $2,427
Rental Structure: Triple Net Annual Rent:$29,122
Space Available: 1,765 SF
Floor: 3 Lease Term: Negotiable
Description: O,R&L Commercial is pleased to offer a 48,000 SF professional "Class A" Office / Medical building for Lease on East Main Street in the town of Branford, CT. Sound deadening insulation in interior walls creates a private, and quiet professional atmosphere. Two large elevators and ADA compliant bathrooms for accessibility. Large windows with lots of natural light potential. Availability includes: 860 SF, 1,765 SF, 1,902 SF, (3,667 SF contiguous) on the 3rd floor and 1,437 SF available on the 2nd floor with elevator access. The property offers ample on-site parking for patrons and exclusive tenant parking. Route 1 location with many area amenities nearby and convenient access to I-95 Exits 55 and 56. All existing tenants are professional / medical uses. Lease Rate: $16.50/SF NNN
Rent / SF: $16.50 Monthly Rent: $1,183
Rental Structure: Triple Net Annual Rent:$14,190
Space Available: 860 SF
Floor: 3 Lease Term: Negotiable
Description: O,R&L Commercial is pleased to offer a 48,000 SF professional "Class A" Office / Medical building for Lease on East Main Street in the town of Branford, CT. Sound deadening insulation in interior walls creates a private, and quiet professional atmosphere. Two large elevators and ADA compliant bathrooms for accessibility. Large windows with lots of natural light potential. Availability includes: 860 SF, 1,765 SF, 1,902 SF, (3,667 SF contiguous) on the 3rd floor and 1,437 SF available on the 2nd floor with elevator access. The property offers ample on-site parking for patrons and exclusive tenant parking. Route 1 location with many area amenities nearby and convenient access to I-95 Exits 55 and 56. All existing tenants are professional / medical uses. Lease Rate: $16.50/SF NNN
Rent / SF: $16.50 Monthly Rent: $1,976
Rental Structure: Triple Net Annual Rent:$23,710
Space Available: 1,437 SF
Floor: 2 Lease Term: Negotiable
Description: O,R&L Commercial is pleased to offer a 48,000 SF professional "Class A" Office / Medical building for Lease on East Main Street in the town of Branford, CT. Sound deadening insulation in interior walls creates a private, and quiet professional atmosphere. Two large elevators and ADA compliant bathrooms for accessibility. Large windows with lots of natural light potential. Availability includes: 860 SF, 1,765 SF, 1,902 SF, (3,667 SF contiguous) on the 3rd floor and 1,437 SF available on the 2nd floor with elevator access. The property offers ample on-site parking for patrons and exclusive tenant parking. Route 1 location with many area amenities nearby and convenient access to I-95 Exits 55 and 56. All existing tenants are professional / medical uses. Lease Rate: $16.50/SF NNN
Rent / SF: $16.50 Monthly Rent: $2,615
Rental Structure: Triple Net Annual Rent:$31,383
Space Available: 1,902 SF
Space Use: Medical / Office
Floor: 3 Lease Term: Negotiable
Description: O,R&L Commercial is pleased to offer a 48,000 SF professional "Class A" Office / Medical building for Lease on East Main Street in the town of Branford, CT. Sound deadening insulation in interior walls creates a private, and quiet professional atmosphere. Two large elevators and ADA compliant bathrooms for accessibility. Large windows with lots of natural light potential. Availability includes: 860 SF, 1,765 SF, 1,902 SF, (3,667 SF contiguous) on the 3rd floor and 1,437 SF available on the 2nd floor with elevator access. The property offers ample on-site parking for patrons and exclusive tenant parking. Route 1 location with many area amenities nearby and convenient access to I-95 Exits 55 and 56. All existing tenants are professional / medical uses. Lease Rate: $16.50/SF NNN

Building Details

  • Tenancy: Multitenant
  • Building Area (SF): 48,000
  • Year Built: 1990
  • Number of Stories: 3
  • Number of Buildings: 1
  • Building Class: B

Land Details

  • Acreage: 2.62
  • Gas: Yes
  • Sewage System: Public Sewer
  • Water System: Public Water

Documents for 500 East Main Street, Branford, CT 06405

FLYER 500 East Main St_Branford.pdf

The Office / Medical property at 500 East Main Street, Branford, CT 06405 is currently available for lease. Contact Will Braun from O,R&L Commercial, LLC for more information.

More like this: Office Space for Lease in New Haven County (9)· Medical Office Space for Lease in New Haven County (5)· Office Space for Lease in Connecticut (41)· Medical Office Space for Lease in Connecticut (10)· Commercial Real Estate for Lease in Branford (5)· Commercial Real Estate for Lease in New Haven County (16)· All listings from O,R&L Commercial, LLC (13)

About this area: Branford, CT

Conn-Comp market snapshot

Office sales in Branford, last 12 months

6
sales recorded
$246
median price per SF
$150 - $261
middle half, per SF
$943,000
median sale price
67% of sales were financed. Median price per SF up 45% from the prior 12 months. New Haven County: 102 sales, median $142 per SF, average mortgage rate 7.26%. October 2025 through September 2026. Source: Conn-Comp Sales Data, verified Connecticut sales and recorded mortgages. For verified sales data, use Sales Data Login

Branford's commercial property runs along US 1 (Main Street and West Main Street), the I-95 interchanges and the town center, with industrial and flex buildings along Route 1 and in the industrial areas near the rail line. Shore Line East stops in town, and Tweed New Haven Airport is about 3 miles west. Health care, local government, restaurants and retail are the largest job sectors.

Population28,217
Jobs located here17,003
Largest employersBausch+Strobel, Blakeslee Prestress, Connecticut Hospice, Massey's Plate Glass & Aluminum, Premeiere Auto Group
HighwaysI-95, US 1, Route 139, Route 142, Route 146
People within a 45-minute drive1,262,357
Median household income$105,225
CountyNew Haven County

Town facts: AdvanceCT and CTData Collaborative, 2026 Town Profile

All commercial real estate for lease in Branford · Connecticut market report